Vasculitis

Overview

  • Inflammation w/in blood vessel walls causing end-organ damage often a/w systemic sx; may be primary or secondary (eg, infection, malignancy) in etiology
  • Classified by size of predominant vessel affected (Arthritis Rheum 2013;65:1); overlap of vessel size affected is common
  • Clinical manifestations based on size of vessels involved; constitutional sx (low-grade fever, fatigue, weight loss, myalgias, anorexia) common to all
Distinguishing Characteristics of Vasculitis Subtypes
Large Vessel Medium Vessel Small Vessel
TAK GCA PAN ANCA-Assoc. IC
Epidem Young, ♀ > ♂ Elderly, ♀ > ♂ Middle-aged to older Variable Variable