Systemic Lupus Erythematosus (SLE)

Multisystem inflammatory autoimmune disease with a broad spectrum of clinical manifestations in association with antinuclear antibody (ANA) production

Epidemiology (Lancet 2014;384:1878)

  • Prevalence 15–50/100,000; predominantly affects women 2nd to 4th decade
  • ♀:♂ ratio = 8:1; African American:Caucasian ratio = 4:1
  • Complex genetics; some HLA association; rarely C1q & C2 deficiency
Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria
Clinical Criteria SLICC Classification Criteria* Other Clinical Features
Constit (84%) Fever, malaise, anorexia, ↓ wt
Cutaneous/Oral/ Ophthalmologic
1. Acute or subacute cutaneous changes
2. Chronic cutaneous changes
3. Oral or asal ulcers