Lung Cancer

Pathology and Genetics
Pathology % Typ locat. Genetic Mutations in
Non-small Cell Adenocarcinoma 40 Peripheral KRAS (20–30%), EGFR (15–20%, esp. ♀, Asian, never smokers), HER2 (6%) or rearrang. in ALK (~4%), ROS1 (~2%) and RET (~1%)
Squamous 20 Central FGFR1, SOX, PIK3CA, PTEN, TP53, SOX2, DDR2, BRAF
Large cell 5 Peripheral
Other/not classif. 20
Small cell 15 Central Complex; most have inactiv. of TP53 and RB1
(NEJM 2008;359:1367; JCO 2012;30:863; J Thorac Oncol