Hematopoietic Stem Cell Transplantation (HSCT)

Transplantation of donor pluripotent cells that can reconstitute all recipient blood lineages
Categories of Stem Cell Transplantation
Feature Allogeneic (Allo) Autologous (Auto)
Donor-recipient relationship Immunologically distinct Donor is also recipient
Graft-vs.-host disease Yes No
Graft-vs.-tumor effect Yes No
Risk of graft contam. w/ tumor No Yes
Relapse risk (leukemia) Lower Higher
Transplant-related mortality Higher Lower
  • Types of Allo HSCT: based on donor/recipient matching of major HLA antigens on Chr. 6 (4 principal genes for serotyping: HLA-A, -B, -C, & -DR; each w/ 2 alleles ∴ 8 major