• Malignant disorder of lymphoid cells that reside predominantly in lymphoid tissues
  • Generally characterized as Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL)

Clinical manifestations

  • Lymphadenopathy (nontender)
    • HL: Reed-Sternberg (RS) cells; superficial (usually cervical/supraclavicular) ± mediastinal LAN; nodal disease with orderly, anatomic spread to adjacent nodes
    • NHL: diffuse; nodal and/or extranodal disease with noncontiguous spread; symptoms reflect involved sites (abdominal fullness, bone pain)
  • Constitutional (“B”) symptoms: fever (>38°), drenching sweats, ↓ weight (>10% in 6 mo)
    • HL: periodic, recurrent “Pel-Ebstein” fever; 10–15% have pruritus; ~35% “B” symptoms