Myelodysplastic Syndromes (MDS)

Myeloid neoplasm overview (Blood 2016;127:2391)

  • Categories based on clinical features, morphology, immunophenotyping, and genetics
WHO 2016 Classification of Myeloid Neoplasms & Acute Leukemia
Acute myeloid leukemia Clonal myeloid stem cell (SC) disorder w/ ≥20% blasts
Myelodysplastic syndromes Dysplastic clonal myeloid SC disorder → cytopenias; <20% blasts, risk of leukemic transformation
Myeloproliferative neoplasms Nondysplastic multipotent myeloid SC clonal expansion
MDS/MPN neoplasms Features of MDS & MPN (eg, CMML, atypical CML)
Myeloid/lymphoid malig. w/ eos & rearrangements of PDGFR or FGFR1 or w/ PCM1-JAK2 May be responsive to TKI therapy (eg, imatinib) or