Transfusion Therapy

Blood Products and Indications (Lancet 2013;381:1845)
Packed red blood cells (PRBCs) (JAMA 2016; 316:2025) For acute blood loss or to ↑ O2-carrying capacity if end organ ischemia. 1 U PRBC → ↑ Hb by ~1 g/dL. Hb goal >7 g/dL adequate for UGIB & critically ill (NEJM 2013;368:11 & 2014;371:1381); maybe >9 if cancer & septic shock (Crit Care 2017;45:766). Controversy re: coronary ischemia, although Hb 7–8 likely adequate ( AHJ 2018;200:96), including peri-cardiac surg (NEJM 2018;379:1224).
Platelets (plts) (Annals 2014;162:205) For plts 10k (