Sepsis and Shock

Definitions (JAMA 2016;315:801; 2017;317:290 & 301)
Sepsis Life-threatening organ dysfxn (SOFA ≥2) due to infection
Quick SOFA (qSOFA): ≥2 of the following: RR ≥22, ΔMS, SBP ≤100 mmHg
Septic shock Sepsis-induced circulatory and cellular/metabolic abnormalities severe enough to ↑ mortality; hypotension requiring pressors for MAP ≥65 and lactate >2 despite adequate fluid resuscitation
Sequential Organ Failure Assessment (SOFA): ↑ points for worsening organ dysfxn: respiration (↓ P:F ratio); coag (↓ plt); liver (↑ bili); CV (↓ MAP or ↑ pressors); CNS (↓ GCS); renal (↑ Cr or ↓ UOP)

Systemic lammatory response syndrome (SIRS):