TRK Signaling Pathway

    • The tropomyosin-related kinases (TRKs) are neurotrophin receptors from the tyrosine kinase family and consist of three members: TRKA, TRKB, and TRKC, which are encoded by NTRK1, NTRK2, and NTRK3 genes. The corresponding in vivo ligands are as follows: TRKA—neurotrophic growth factor (NGF) and neurotrophin-3 (NT-3); TRKB—brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4); TRKC—NT-3 (Amatu et al., 2016).
    • The TRK receptor family is involved in neuronal development, including the growth and function of neuronal synapses. In adults, TRK receptors regulate memory, body weight, appetite, proprioception, pain, and thermal regulation.
    • Tropomyosin sequences cause MAPK, PI3K, and PLCg pathways, resulting in cell proliferation, increased cell survival, and migration leading to tumor growth.
    Other topics in Molecular Targets and Pathways