Aurora Kinases

    • Serine/threonine kinases that regulate important aspects of mitosis include chromosome segregation and the spindle checkpoint during the S phase of cell cycle.
    • Defects in segregation lead to genetic instability, which is highly associated with tumorigenesis.
    • Aurora kinases can be mutated or amplified in cancer cells.
    • Three aurora kinases are identified in mammalian cells and have generated significant interest in cancer research.
    • Aurora A kinase (AURKA)
      • Required for correct function of centrosomes
      • Expression levels kept in check by tumor suppressor gene p53
      • Mutations of chromosome region that contains aurora A, 20q13, are rally associated with poor prognosis
    Other topics in Molecular Targets and Pathways