Targeting DNA Damage Response

    (Reprinted from O’Connor MJ. Targeting the DNA damage response in cancer. Mol Cell. 2015;60(4): 547–560. With permission from Elsevier.)
    • Poly (ADP-ribose) polymerase (PARP) is a protein family involved in many cellular processes in the nucleus involving mainly DNA repair and PD (apoptosis).
    • PARP family consists of 17 members, each with different structures and functions in the cell. The most characterized is PARP-1.
    • PARP-1 inhibitors (olaparib and rucaparib) are FDA approved for patients with ovarian cancer with BRCA1/2 mutations. Niraparib is also a PARP inhibitor that is cancer regardless of the presence of BRCA1/2 mutations.
    Other topics in Molecular Targets and Pathways