DNA Damage Response

    (Reprinted from O’Connor MJ. Targeting the DNA damage response in cancer. Mol Cell. 2015;60(4): 547–560. With permission from Elsevier.)
    • Human cells are constantly exposed to exogenous and endogenous factors that might damage the genomic integrity and its correct transmission to the next generation.
    • To respond to these threats, cells have developed an arsenal of enzymatic tools called DNA damage response (DDR).
      • Modified bases and the DNA single-strand breaks (SSBs) are the most common form of DNA damage, and these are repaired by the base excision repair BER) pathway.
    Other topics in Molecular Targets and Pathways