• TP53 gene encodes for cellular tumor antigen or phosphoprotein p53 (name is in reference to apparent molecular mass of 53 kDa).
    • Main function of TP53 is prevention of damage to genome, making it a tumor suppressor.
    • TP53 acts as a transcriptional activator to several hundred genes.
    • TP53 is an important regulator of G1/S and G2/M checkpoints.
    • Considered the most frequently mutated gene in cancer
    • Mutations may be inherited or sporadic.
    • MDM2 is a negative regulator of TP53.
    • MDM2 responsible for rapid turnover of TP53 (half-life 10–20 min)
    Other topics in Molecular Targets and Pathways