Cell Cycle Regulation

  • Regulation of cell cycle is partially mediated through MAPK and PI3K pathways as previously described.
  • Cell cycle regulation is crucial for mitigating genomic instability and preventing replication fork collapse. The ATR/CHK1 and ATM/CHK2 axes perform key roles in cell cycle regulation. Ataxia telangiectasia mutated kinase (ATM) is important in activation of tumor suppressor gene TP53. TP53 and RB1 are two of the most frequently mutated genes in cancer, and the loss of these genes’ function leads to cellular hyperproliferation and evasion of apoptosis.
  • In addition to hyperproliferation, the loss of TP53 on decreases the dependence of tumor cells on external growth factors and prevents catastrophic genomic instability.
Other topics in Molecular Targets and Pathways