Death Receptors and Apoptosis

    • Death receptors include Fas, TNF-R, DR3, and DR 4/5.
    • After binding of ligands (e.g., FasL, TNF-α, AP0-3L/TWEAK, AP0-2L/TRAIL), death receptors form dimers or trimers and recruit adaptor proteins that activate the caspase (casp) cascade via the mitochondria, which ultimately leads to apoptosis.
    • Fas receptor (also known as apoptosis antigen 1: APO-1 or tumor necrosis factor receptor superfamily member 6 or TNFRSF6) forms the death-inducing signaling complex (DISC) as a result of ligand (FasL) binding.
    • DISC is composed of the death receptor, adaptor protein FADD (Fas-associated protein with death domain), and caspase 8.
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