SRC Pathway

    • SRC (short for sarcoma) is a family of nonreceptor protein TKs that play an important role in the regulation of cell adhesion, invasion, and motility by phosphorylating specific tyrosine residues in other proteins such as RAS, CAMs (e.g., FAK, focal adhesion protein), and cadherins (e.g., E-cadherins).
    • FAK activation by SRC is particularly important for cell adhesion and motility that leads to metastasis.
    • SRC activates RAS pathway via SHC.
    • SRC also activates E-cadherin, a tumor suppressor that regulates cell invasion.
    • Activation of pathway is observed in approximately 50% tumors from colon, liver, g, breast, and pancreas.
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