Wnt Pathway

    • The Wnt signaling pathway is pivotal in cell proliferation, differentiation, growth, survival, development, regeneration, and homeostasis.
    • Signaling is initiated by binding of the Wnt proteins to their seven-pass transmembrane receptors called Frizzled (FZD), which then activates B-catenin.
    • In the absence of the ligand, the Wnt pathway is in an “off” state with B-catenin phosphorylated and targeted for degradation. In the “on” state, however, FZD is activated by ligand binding, which then inhibits phosphorylation and results in the translocation of B-catenin to the nucleus.
    • B-catenin initiates the transcription of its target gene (Tcf)/lymphoid enhancer factor (Lef) family. These regulate the cell cycle including c-myc and CCND1.
    Other topics in Molecular Targets and Pathways