NOTCH Pathway

    (Adapted from Andersson ER, Lendahl U. Therapeutic modulation of Notch signalling–are we there yet? Nat Rev Drug Disc. 2014; 13(5):357–378. Adapted by permission from Springer Nature.)
    • NOTCH is a family of four transmembrane receptors (NOTCH 1–4) that are involved in cell–cell interaction and is found in most multicellular organisms.
    • NOTCH signaling is critical to the differentiation and maintenance of several organs that include skin, blood, intestine, liver, and muscle.
    • In cancers, mutations in NOTCH can either be activating or inactivating, attributing it as an oncogene or f its tumor suppressive function, respectively.
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