Hedgehog Signaling Pathway

    • The Hedgehog (Hh) pathway can be simplified into four fundamental components: (a) the ligand Hedgehog, (b) the receptor Patched (Patch), (c) the signal transducer Smoothened (Smo), and (d) the effector transcription factor (Gli).
    • Canonical Hh signaling occurs predominantly in the primary cilium (Ng and Curran, 2011). Primary cilia (PC) are tubulin-polymerized immotile cilia that assemble from the centriole at the end of mitosis.
    • Components of the Hh pathway concentrate in PC (Ramsbottom and Pownall 2016; Roy 2012) and a complex PC trafficking system regulates the interaction of Hh pathway components to ce, or block, the Hh-initiated signal.
    Other topics in Molecular Targets and Pathways