JAK/STAT Pathway

    • Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway transmits information through the cell membrane from chemical signals outside the cell and into genome DNA sites to regulate cell growth and differentiation.
    • Many JAK/STAT pathways are important in white blood cells, mammary gland, adipocytes, neuronal cells, cardiomyocytes, hepatocytes, stem cells, and the like, and JAK/STAT deregulations may contribute to development of various diseases including immune diseases and cancers.
    • There are four JAK family members (JAK1, JAK2, JAK3, and JAK4 or TYK2) and seven STAT family members (STAT1, STAT2, STAT3, STAT4, T5A, STAT5B, and STAT6).
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