Targeting mTORC1 and mTORC2

    • Mammalian target of rapamycin (mTOR) can be referred to a class IV PI3K.
    • It exists in two distinct complexes (mTORC1 and mTORC2); mTORC1 is composed of the mTOR catalytic subunit, regulatory-associated protein of mTOR (raptor), proline-rich AKT substrate 40 kDa (PRAS40), and the protein mLST8. mTORC2 is composed of mTOR, Rictor, mammalian stress-activated protein kinase interacting protein 1 (MSIN1) and mLST8.
    • mTORC1 regulates cell growth by modulating many processes such as protein synthesis and autophagy in response to upstream factors (e.g., PI3K, TSC complex, growth factors).
    • mTORC2 directly activates AKT.
    • Although l, endometrial, and lung cancers and can be hyperactivating. These mutations are sensitive to rapamycin. In addition, amplifications in members of the complex such as raptor have been seen.
    Other topics in Molecular Targets and Pathways