Targeting RAS

    • Rat sarcoma viral oncogene homolog (RAS) encodes a proto-oncogene protein that acts as a pivotal point for integration of growth factor signal initiation. Mutations in Ras kinases family have been detected in up to 30% of human cancers. Somatic mutations in Kras are considered the most common, found in 25% to 30% of the screened samples, in comparison with NRAS or HRAS (8% and 3%, respectively).
    • RAS kinases family includes three isoforms: KRAS, HRAS, and NRAS.
      • KRAS mutations are commonly found in pancreatic cancer, colon cancer, ur in codons 12, 13, and 61, which cause permanent state of activation that result from loss of GTPase activity.
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