MAPK Pathway

    • Signaling through the RAS/RAF/MEK/ERK (MAPK) pathway is essential for the proliferation of normal cells as well as for many cancer cells.
    • Activation of pathway occurs through growth factor binding to RTKs and also by other extra- and intracellular stimuli.
    • Mitogen-activated protein kinases (MAPK) are involved in directing cellular responses to a variety of stimuli and help regulate proliferation, gene expression, and apoptosis among others.
    • In cancer cells, pathway signaling is often heightened as a consequence of oncogenic activation of RTKs, RAS, or RAF. The pathway cascade ultimately leads to ERK activation.
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