• Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-KIT or tyrosine protein kinase KIT or CD117, is a protein that in humans is encoded by the KIT gene.
    • Receptor is activated by binding of stem cell factor (SCF), also known as “c-KIT ligand.” Signaling through c-KIT plays a role in cell survival, proliferation, and differentiation.
    • Multiple transcript variants encoding different isoforms have been found for this gene.
    • Hematopoietic stem cells (HSC), multipotent progenitors (MPP), common myeloid progenitors (CMP), and early thymocyte progenitors in the thymus express high levels of s low levels of c-KIT. In addition, mast cells, melanocytes in the skin, and interstitial cells of Cajal in the digestive tract express c-KIT.
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