RET Receptor

Normal Biology

  • REarranged during Transfection (RET) receptor can activate MAPK and PI3K pathways similar to EGFR.
  • RET is a receptor for the glial cell line–derived neurotropic factor (GDNF) family of extracellular ligands.

Role in Cancer

  • Point mutations in RET give rise to multiple endocrine neoplasia syndromes (MEN2) and familial medullary thyroid cancer.
  • Chromosomal rearrangements that create a fusion between RET and other proteins can cause constitutive activation of RET receptor.
  • Fusions of RET with other genes have been identified in multiple malignancies.
    • Found in approximately one-third of patients with papillary thyroid er. Associated with radiation exposure.
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