TIE Receptors

    • Angiopoietin growth factors (ANG) bind to cell surface RTKs with immunoglobulin-like and epithelial growth factor–like domains 1 and 2 (TIE1 and TIE2).
    • Four different ANGs have been identified (ANG1, ANG2, ANG3, and ANG4).
    • ANG1 and ANG4 are agonists for TIE2, whereas ANG2 and ANG3 are competitive antagonists for TIE1 and TIE2.
    • Activation of TIE2 by ANG1 is indispensable for embryonic cardiac development and angiogenesis, and both TIE1 and TIE2 are key regulators of normal formation of blood and lymphatic vessels development as TIE1 and TIE2 are almost exclusively expressed in the endothelium.
    Other topics in Molecular Targets and Pathways