PDGFR and Targeting PDGFR

    • Platelet-derived growth factors (PDGFs) are potent mitogens for cells of mesenchymal origin and are synthesized, stored, and released by platelets upon activation; also produced by smooth muscle cells, activated macrophages, and ECs.
    • PDGF signaling network consists of four ligands (PDGF A–D) and two transmembrane tyrosine RTKs (PDGFRα and PDGFRβ).
    • These receptors transmit extracellular growth factor signaling to intracellular signaling cascades. Upon binding of the growth factor ligands, the receptors undergo dimerization and autophosphorylation of cytoplasmic kinase domains, activating the receptor.
    • Downstream effects of PDGFR activation leads to differential signaling through MAPK, JAK/STAT pathways resulting in cell proliferation, cell differentiation, survival, and migration.
    Other topics in Molecular Targets and Pathways