Targeting the FGFR Pathway

    TARGETS FGFR1 FGFR2 FGFR3 FGFR4 Other Target
    FDA-approved small-molecule inhibitors Pazopanib VEGFR-1–3, PDGFRα/β, KI
    Ponatinib VEGFR-2, TIE FLT3, SRC
    Regorafenib VEGFR-2, KIT, RET, PDGFRβ
    Lenvatinib VEGFR-1–3, PDGFRα, KIT, RET
    Inhibitors in clinical trials JNJ-42756493
    LY2874455
    NVP-BGJ398 VEGFR-2
    TAS120
    AZD4547 VEGFR-2
    Debio-1347
    Dovitinib VEGFR-1–3, PDGFRβ
    Nintedanib VEGFR-1–3, PDGFRα/β, FL
    Brivanib VEGFR-2
    Lucitanib
    Other topics in Molecular Targets and Pathways