VEGFR Signaling and Targeting VEGFR

    • Vascular endothelial growth factor (VEGF) is one of the most important and prominent proangiogenic factors. VEGF’s normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
    • The VEGF family consists of five members (VEGF-A, -B, -C, -D, and placental growth factor [PIGF]), which transmit signals via three VEGF receptors (VEGFR-1 through -3).
    • Many human cancers are found to overexpress VEGFs and/or VEGFRs.
      • VEGFR-1 binding by VEGF-B plays a role in the maintenance of ly formed blood vessels.
    Other topics in Molecular Targets and Pathways