Receptor Tyrosine Kinases

    • Receptor tyrosine kinases (RTKs) are cell surface receptors that function as key regulators of fundamental cellular processes such as proliferation, differentiation, senescence, and migration, among others.
    • Binding of growth factor ligands to extracellular domain, RTKs induces receptor dimerization (forming either homodimers or heterodimers with other RTKs) followed by their autophosphorylation. This allows for subsequent recruitment of adaptor proteins such as growth factor receptor-bound protein 2 (GRB2), SRC homology 2 domain-containing protein (SHC), and Son of Sevenless (SOS) that activate proliferation, survival, and migration pathways (e.g., RAS, PI3K, SRC).
    • Tight control of necessary for tissue homeostasis, which is why RTKs constitute one of the biggest classes of oncoproteins.
    Other topics in Molecular Targets and Pathways