Induction of Tumor Angiogenesis

    Effectors
    Proangiogenic Antiangiogenic
    Gain of function: Oncogenes
    PI3K ↑VEGF
    HRAS ↑VEGF ↓TSP-1
    EGFR ↑VEGF, ↑FGF, ↑IL-8
    ERBB2 ↑VEGF
    BCL2 ↑VEGF
    SRC ↑VEGF ↓TSP-1
    FOS Induce VEGF expression
    Loss of function: Tumor suppressor genes
    TP53 ↑VEGF ↓TSP-1
    VHL ↑VEGF
    PTEN ↑VEGF
    RB ↓TSP-1
    (Adapted from Wicki A, Christofori G. The angiogenic switch in tumorigenesis. In: Marmé D, Fusenig N, eds. Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. Berlin, Heidelberg: Springer; 2008: 73, chap 4.)
    Other topics in Molecular Targets and Pathways