Angiogenesis Regulators

    • Hypoxia or low oxygen tension results from uncontrolled proliferation of cancer cells in the absence of a functional and adequate vascular bed. It is a major driver of tumor angiogenesis.
      • Under normoxic conditions, hypoxia-inducible transcription factor-1 alpha (HIF-1α) subunits are subjected to von Hippel-Lindau (VHL)-directed protein degradation. VHL itself is a tumor suppressor, and VHL mutations have been implicated in malignancies such as renal cell carcinoma.
    • Hypoxic conditions stabilize HIF-1α, allowing it to translocate to the nucleus, and, along with HIF-1β, initiate the transcription of proangiogenic genes such as VEGF. Examples tumors include the following:
    Other topics in Molecular Targets and Pathways