• Angiogenesis is a hallmark of cancer represented by the development of new blood vessels to keep up with the tumor needs, a process that is tightly controlled by pro- and antiangiogenic chemical signals.
    • The angiogenic switch occurs when, in the hypoxic and inflammatory context of cancer, proangiogenic signals outweigh antiangiogenic signals, leading to tumor neovascularization. The shift in balance toward proangiogenic signals favors the abnormal and rapid growth and proliferation of local blood vessels.
    • The sprouting of new blood vessels from the existing vasculature is the most widely investigated mode of five other mechanisms of new vessel recruitment:
    Other topics in Molecular Targets and Pathways