Inflammation and Inflammatory Cytokines

Inflammation and Tumor Promotion

Virtually, every tumor deposit contains inflammatory cells ranging from sparse infiltrations detectable only with cell type–specific antibodies to dense cellular infiltrates apparent by standard light microscopy (DeNardo et al., 2010). These inflammatory cells supply a whole array of molecules: growth and survival factors, proangiogenic factors, matrix-modifying enzymes that facilitate invasion and metastasis, and inducers of EMT and reactive mutagenic oxygen species (Grivennikov et al., 2010). It is quite possible that some of the beneficial effects of chemotherapy actually may be due to decreasing the activity of sensitive, lls even when the cancer cells themselves have acquired chemotherapy resistance.